Indications to Use of Donor Eggs

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Following the long process of medical consultations with infertility treatment experts, many family couples take a decision to make use of the services of an egg donor. As shown by the medical practice of many years, a woman who got pregnant with the help of a fertilized donor oocyte experiences no alarming symptoms as regards the fact that her baby is genetically related to the father only, either in the course of pregnancy or after the birth. The emotions of happiness, feeling of joy as a result of perception of movement of a tiny body inside, baby’s heartbeat displace all negative thought about the fact that this little human being came to life in the unnatural way.  

Application of the oocyte donation method may only be based on the relevant medical indications, the written voluntary consent to be given by a patient, maintenance of egg donor anonymity and medical secret.

Law of UkraineProcedure of Application of Attendant ReproductiveTechnologiessets the following list of medical indications to the use of donor oocytes:

  • acquired or inborn lack of oocytes, which is attributed to natural menopause;
  • risk to convey any genetic disease to a would-be child;
  • absence of ovaries as a result of surgical interference;
  • abnormal development of ovaries;
  • poor response of ovaries to stimulation of superovulation, loss of oocyte generation function;
  • repeated cultivation of inferior-quality embryos;
  • a woman is older than 40.

List of Essential Documents

  • voluntary donor’s consent to donate oocytes;
  • application of patients for the use of donor oocytes.

Scope of Medical Tests to be Passed by Female Patients:

1) obligatory tests:

  • therapist’s conclusion as regards health condition;
  • identification of blood group and rhesus-factor;
  • clinical blood analysis;
  • coagulogram (coagulability);
  • blood test for syphilis, AIDS, hepatitis B and C;
  • blood tests (IgM, IgG) for toxoplasmosis, clamydia, cytomegalovirus and rubella;
  • bacterioscopic tests of discharges from vagina, urethra and cervical channel;
  • cytological examination of cervical smears;
  • general gynecological examination;
  • ultrasonic scanning of small-pelvis organs;
  • blood test for anti-Mullerian hormone (AMH), prolactin, (Prl), follitropin  (FSH), lutropin (LH), progesterone (P), estradiol (E2)

2) according to extra medical indications, the following tests can be possible:

  • examination of uterus and uterine tubes (hysterosalpingography, sonosalpingoscopy, laporoscopy, hysteroscopy);
  • colposcopy;
  • endometrium biopsy;
  • blood test for testosterone (T), cortisol (C), thyroxin (T3), triiodothyronine (T4), thyrotropin (TTH), somatotropin (STH);
  • determination of blood glucose level;
  • test for anti-spermal bodies and anti-phospholipid antibodies;
  • test for antibodies to thyreoglobulin, thyreoperoxidase and anti-microsomal antibodies;
  • test for symptoms of anti-phospholipidic syndrome and other immune system disorders;
  • tests for urinogenitalia and TORCH-infections;
  • karyotyping. medical-genetic consultation, as well as other molecular-genetic examinations;
  • fluorography;
  • ultrasonic scanning of internal organs and thyroid gland;
  • ultrasonic testing of mammary glands for women not older than 40 and mammography for women older than 40;
  • biochemical blood test: kidney sampling, liver sampling, common bilirubin, protein fractions, glucose.

 Oocyte donation algorithm :

  • synchronization of menstrual cycles of recipient and oocyte donor;
  • stimulation of donor superovulation;
  • preparation of recipient endometrium for embryo transfer;
  • application of in-vitro fertilization methods, in particular, ICSI (intracytoplasmic sperm injection);
  • donor oocytes can be cryopreserved for the purposes of their further use;

As a rule, IVF involving the use of donor oocytes provides for a higher chance of success, since the fertility of a donor is already proved by nature itself.