New IVF methods

The number of couples having recourse to IVF in hope to attain pregnancy grows with each passing year.

Regretfully, the use of this infertility treatment method may have negative consequences in respect of some women, since the procedure itself involves application of an extensive range of strong hormonal medicines.

Being aware of severity of the IVF disadvantageous aspect, English reproductologists made an attempt to improve this method. As a result of thorough studies they managed to attain the desired result and identify the kisspeptin natural hormone being capable of enhancing superovulation of IVF-treated women without any harmful results.

The in-vitro fertilization procedure involves collection of male and female genetic matter with their further combination under artificial medium conditions with the purpose of producing embryos, a certain number of which are to be transferred into the uterine cavity of a woman with the use of a thin catheter at the relevant stage of their cultivation. Naturally, to run this procedure successfully, a woman must be subject to the superovulation procedure for the purpose of making mature the maximum possible number of follicles instead of just one oocyte. Superovulation involves injection of strong-acting synthetic hormones into the muscle tissues. Such hormonal substances often cause hyperstimulation of ovaries, thus lowering the rate of success of implantation of embryo/embryos and onset of pregnancy.

Hyperstimulation causes inflammation of ovaries. Being in this condition, a woman may suffer heavy abdominal distension, painful sensations in the bottom of her stomach, nausea and vomiting. 

The IVF study, involving the use of the kisspeptinhormone, showed good results.  The kisspeptin-containing drugs stimulating the growth of oocytes were injected to 53 women. 51 women attained the condition of superovulation with no hyperstimulation being caused. According to the research group, this is due to the property of kisspeptin to be withdrawn from blood rather fast.

Currently, it is planned by reproductologists to focus their study on women who suffer polycystic ovary syndrome and indend to make use of the IVF process.